In fourteenth-century England, peasant girl Christine Carpenter is so attracted to a statue of the Virgin Mary that the local priest (who lusts after her) suggests she be walled up in the church as an anchoress, a holy woman with responsibility for blessing the villagers. But when the priest has Christine's mother tried as a witch, she digs herself out of her cell, a crime for which the punishment is death.
When a mysterious virus created by a Japanese doctor in Tokyo escapes containment, the world spirals into chaos. A medical anomaly quickly mutates into a global phenomenon-manifesting in eerie, unpredictable forms across two continents.