Volcanoes, earthquakes, and tornadoes all can cause enormous damage, and predicting where and when they will strike is of great importance. Volcanologist Dr. Marie Edmonds has devised sensors that monitor the underground activity of magma to better predict future eruptions on the Caribbean island of Monserrat, the site of the massive 1995 eruption captured for this film. Geophysicist Dr. Ross Stein studied the earthquake repair records in Istanbul's Hagia Sophia over the centuries to find clues about the history of earthquakes in Turkey. He discovers a pattern in quakes along the long North Anatolian Fault system, including the massively destructive quake at Izmit in 1999, and predicts the next earthquake just a few miles south of Istanbul. Dr. Joshua Wurman and his team chase tornados in trucks equipped with Doppler radar in an attempt to probe the interior of a tornado just as it is born.
When a mysterious virus created by a Japanese doctor in Tokyo escapes containment, the world spirals into chaos. A medical anomaly quickly mutates into a global phenomenon-manifesting in eerie, unpredictable forms across two continents.