Two untalented singers (Sam Rockwell, Steve Zahn) are mistaken for a pair of major league safecrackers in Providence, Rhode Island. The two are pressed into service by the local hoodlums and quickly find themselves in conflict with their professional colleagues. Romantic interest is added by the daughter (Christina Kirk) of the underworld leader (Harvey Fierstein) who won't date the men she knows are gangsters.
When a mysterious virus created by a Japanese doctor in Tokyo escapes containment, the world spirals into chaos. A medical anomaly quickly mutates into a global phenomenon-manifesting in eerie, unpredictable forms across two continents.