英国首相（伊德里斯·艾尔巴 Idris Elba 饰）和美国总统（约翰·塞纳 John Cena 饰）的公开争执让两国联盟岌岌可危。然而，当他们成为某个强大势力的袭击目标后，这对冤家不得不放下分歧，展开一场横跨多国的疯狂行动。在军情六处精英特工诺埃尔（佩丽冉卡·曹帕拉 Priyanka Chopra 饰）的协助下，他们必须想方设法挫败那个威胁整个自由世界的惊天阴谋。
The story is said to follow a pair of loner college undergrads, Jack and Montgomery, who order a take-out pie, but accidentally take a homemade drug that turns a two-floor journey downstairs into a “mind-bendingly transformative quest.”
On the verge of losing everything, veteran sprinter Gu Young is getting one last opportunity at redemption, including a chance to re-kindle the love of his life.
